The following sentence appears in the alt.tv.southpark FAQ:
I think actually may know the answer to this.
At the time of his reign, King Kamehameha weighed approximately 400 pounds. Subsequently, if something is 'King Kamehameha' it is 'larger-than-life.'
So if Kyle's Mom is being a "King Kamehameha Bee-otch" , that seems to simply mean she's being more of a beeotch than usual. :-) YMMV.
BMM