Heard this one last night in LA on the 11:30 pm broadcast of the episode, (FABF14 - Catch 'Em If You Can) where Bart and Lisa and Grandpa chase Marge and Homer to Florida and beyond as the couple seek to escape for the weekend.
Homer: "Lisa, as it says in the Bible, 'Screw That.'"
Another great line from the show was when the gay fellow put his hand on Grandpa's shoulder, Grandpa asks, "You're not going Lavender on me are you?"
Poor episode, but it had a few good quotes. "SCREW THAT!"
DB