The title of tonight's episode is "Little Girl in the Big Ten." Although this title is a play on the phrase "little girl in the big city," if Lisa were to literally go to one of the colleges which are in the Big Ten Conference of American College sports, then Springfield would have to be in or near one of these cities (considering she is only 8 and can't really drive there-and Homer wouldn't want to drive her, either):
Champaign, Illinois (Illinois Fighting Illini) Bloomington, Indiana (Indiana Hoosiers) Iowa City, Iowa (Iowa Hawkeyes) Ann Arbor, Michigan (Michigan Wolverines) East Lansing, Michigan (Michigan State Spartans) Minneapolis, Minnesota (Minnesota Golden Gophers) Evanston, Illinois (Northwestern Wildcats) Columbus, Ohio (Ohio State Buckeyes) State College, Pennsylvania (Penn State Nittany Lions) West Lafayette, Indiana (Purdue Boilermakers) Madison, Wisconsin (Wisconsin Badgers)