NEW YORK (CNN) -- An American Airlines jet with 255 people on board crashed Monday in a residential neighborhood after taking off from New York's John F. Kennedy International Airport.
American Airlines Flight 587 went down at 9:17 a.m. EST in the Rockway section of the New York City borough of Queens about five miles from Kennedy airport.
A senior Bush administration official told CNN initial indications are that there was an explosion aboard the plane, an Airbus A300, but that the source of the explosion is unknown.
New York Mayor Rudy Giuliani said there were two crash sites -- one where the plane landed and another where an engine landed. Both were about six blocks from a school building. The school was closed for the Veterans Day holiday.
The plane was scheduled to leave at 8:40 a.m. EST, but takeoff was delayed until 9:14 a.m.
GALLERY Scenes from Monday's New York airplane crash
FACT BOX
American Airlines Flight 587, an Airbus A300 -- 246 passengers, nine crew members
En route from New York to Santo Domingo, Dominican Republic
Scheduled for 8:40 a.m. EST departure
Plane took off at 9:14 a.m. EST
The plane went down at 9:17 a.m. EST
New York declares Level One alert; 44 firetrucks, 200 firefighters dispatched to scene
Three New York-area airports initially shut down, city tunnels and bridges closed
The plane was en route from New York to Santo Domingo, Dominican Republic. American Airlines said the plane was carrying 246 passengers and nine crew members.
An eyewitness told CNN, "I was in my kitchen ... and I saw the plane hit the house behind my house. It was so low, I was ducking almost, then huge fireballs, and I jumped out of the ... window of my house.
"I ran right across the street ... it's unbelievable," she said, overcome by emotion. "It sounded like two planes. It was flying too low, and then it hit. It was like a bomb exploded."
At least four houses were on fire, and a huge plume of smoke could be seen rising from the sites. The New York Fire Department dispatched 44 firetrucks and 200 firefighters to the scene. Giuliani declared a Level One emergency, mobilizing all available police, fire and emergency personnel.
Giuliani said his first response to the crash was, "Oh my God."