Thought I'd throw in my 2 cents as far as Seinfeld being a show about "nothing."
Not to try to make this too profound, but I do think there is one theme that comes through all the humor about "nothing." And that is simply about friendship.
Look at Kramer. A total nut case.....but what a friend! Jerry gets a bad cantaloupe....he takes it back to the store. George's mother needs a ride back from her eye surgery...and not only does Kramer do it, but he is incredibly gracious to George's mother.
Whatever travails the characters go through, it seems that so long as they have each other for support it can all be dealt with.
Ed