Well, it's official: The people who make an episode should also be the ones who promote it. Consistently, it seems that the promotions department (and not just Fox's, either) picks the scenes that least convey the flavor of the show.
If you went just by the promos, you might conclude that "Malcolm in the Middle" was just a series of gross-out jokes, with little heart or likability. In reality, the gross factor is there, but it's balanced with clever humor and characters that are interesting to watch. It isn't a live-action "Simpsons" -- it seems more dysfunctionally out-of-control -- but it has its own style, which in the long run is better. Malcolm is quite personable, and can even carry off the tricky "talking to the camera" plot device. His mom is gruff but obviously cares about her family's welfare (even if it isn't always obvious). The minor characters are good too. I liked Stevie, the wheelchair-using kid Malcolm reluctantly befriends, and the gifted-ed teacher with the nasal voice.
Several scenes stand out. I like the older brother, the one in military school, when he "confessed" his various scenes in montage. The scene where Stevie shows Malcolm his comic collection is actually quite warm. And the resolution is clever and unexpected.
A lot of people will hate "Malcolm," either because of it's ham-fisted promotion, or because it displaced "Futurama." That's unfairly blaming the show for things it can't control. I've been burned on shows that had only one good episode, and then went downhill, but so far "Malcolm" shows promise. It deserves the chance that the network has given it.