Hi I'm a long time reader first time poster, Anyway here is my observation that from what I can see has not been mentioned before, I may be wrong.
After watching "When aliens attack" for the 23rd time, one of my favourite episodes, I noticed that Amy Wong appears to have breast implants. During the beach scene when Nibbler rips off her bikini top she presses two buns up to her chest deforming her breast in a way the would suggest she has implants. Notice the crease along the top of the breast, a good indication they are not 100% real. I don't know how this fits with her comment in the sauna about Genetic engineering and Fry's manhood, it is possible that she was born "small" if you look at her mother.
Am I reading too much into this thing.