Just saw "Roswell that ends well" episode for the first time on CN last nite. What a hoot. Zoidberg was pretty funny. Great to be surprised by a new (for me at least) episode.
In this episode, the writers poke fun at the so-called time-travel paradox, which argues that time travel is impossible because one can inadvertently do something in the past that negates the existence of the time traveler (ie, killing one's granfather before he had children). They get around this by having Fry sleep with grandmother, thus he really was his own grandpa. Sounds good... except... There is a type of DNA which resides in a part of all cells called the mitochondria. This is passed down to offspring only through the mother. So, Fry and his mother both have the same mitochondrial DNA. Which is the same mitochondrial DNA as his grandmother. So therefore... The only way Fry can be his own grandpa is if he sired both his mother AND father by his grandmother, and Fry and is the result of brother/sister mating (who presumably are twins). Ewwww. This does explain Fry's mental slowness...
Having said this, One can understand Leela's reluctance to getting together with Fry. With her own eye, she has seen he is an inbred who is not above sleeping with his grandmother. Unless Leela is from West Virginia, I don't see this being attractive to her...
-jww
PS - I have heard that Dolly the cloned sheep was really not a copy of her mother, because one sheep's nuclear DNA was placed in an egg of another sheep (ie., different mitochondrial DNA).