I was thinking of submitting an episode of Friends in which the gang attends a masquerade party with a catch, they have to dress up as a character from a Cartoon Cartoon show on Cartoon Network. The girls (Rachel, Monica and Phoebe) dress up as The Powerpuff Girls and the men (Joey, Chandler and Ross) dress up as Ed, Edd, and Eddy.
Later on, just as things are going smoothly at the party, Chandler (as Eddy) bumps into Janice (dressed as Swanky the poodle from Sheep in the Big City) and she utters the all-too-familiar catch phrase, Oh...my...God!
(By this time, Janice has divorced her first husband after finding out that she was used to conceive an heir to his family business. She'd took her estranged husband to court and eventually won everything, including custody of her son, Jack. She'd later meet her divorce attorney's cousin, Jake, played by David Arquette, had a whirlwind romance and eventually marries him.)
How everything turns out is a mystery to me, but fans of R&R, M&C, and J&P will be talking about it the next morning.