Ruffie Colatas:
Quagmire is referring to the drug: Rohypnol AKA: "The Date Rape Drug"
Rohypnol is cat tranquilizer, a guy would take a girl to a bar and when the girl went to the bathroom or was distracted, the guy would pour in some ground up Rohypnol(or possible the pill itself), the girl would pass out and he would have his way with her
It is pretty much illegal to even posses this drug let alone use it